Formulation of fast dissolving tablets for olmesartan using hydroxy propyl β-Cyclodextrins

The main objective of the research work is to improve the solubility and dissolution rate of olmesartan medoxomil by complexation with HP β-Cyclodextrins. The inclusion complexes were prepared by kneading method and solvent evaporation method. The prepared complexes were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and by scanning electron microscopy (SEM). The FTIR spectra of olmesartan/ HP βCyclodextrins solid complexes showed that olmesartan medoxomil could form inclusion complex with HPβCyclodextrins in solid state. From the prepared inclusion complexes, fast dissolving tablets were formulated by using superdisintegrant like sodium starch glycolate in various concentrations (10-15%).The influence of diluents like direct compressible lactose and microcrystalline cellulose on the drug release was evaluated. Prepared tablets were evaluated for physical parameters and drug release by in vitro dissolution studies. Dissolution studies showed fast release of olmesartan medoxomil in tablets containing a high level of sodium starch glycolate and microcrystalline cellulose as diluent.